The effects of metformın, acetylsalıcylıc acıd and ıbuprofen on telomerase enzyme actıvıty: ınhıbıtory effect of ıbuprofen

Telomerase enzyme is necessary for the elongation of telomeres while telomerase being critical aging and cancer. Metformin, ibuprofen, acetylsalicylic acid used in this research are drugs that millions people already use many likely to future. In study, effects these on activity Mus musculus swiss albino mice liver tissue were investigated was measured with a PCR-ELISA based kit. study possible connection between activities antioxidant enzymes also by determining superoxide dismutase (SOD) catalase enzymes. The data obtained show metformin slightly decreased low dose application; however, change not statistically significant. ibuprofen application, there significant inhibitory effect when high doses used; whereas, slight at doses. activator detected; it significant, though. Metformin observed increase SOD general acetyl salicylic showed different effects. addition, caused values. It important note demonstrated animal models..